Sarcomatoid Mesothelioma: Diagnostic Challenges and Differentiation

Sarcomatoid Mesothelioma: Diagnostic Challenges and Differentiation What Makes Sarcomatoid Mesothelioma So Difficult to Diagnose? Sarcomatoid mesothelioma is one of the rarest and most aggressive subtypes of mesothelioma, making diagnosis and treatment a real challenge. It consists of spindle-shaped malignant cells, often surrounded by dense collagen deposits, giving it a fibrous appearance. Unfortunately, it can mimic several other spindle cell tumors, leading to misdiagnosis if not carefully evaluated. This article breaks down the key features, differential diagnoses, and essential diagnostic markers that help distinguish sarcomatoid mesothelioma from other similar tumors.