Uncommon Diagnostic Challenges in Epithelioid Mesothelioma

Uncommon Diagnostic Challenges in Epithelioid Mesothelioma Why Diagnosing Epithelioid Mesothelioma Can Be Tricky Mesothelioma is a deceptive cancer, often mimicking other malignancies, making an accurate diagnosis one of the toughest challenges in pathology. In most cases, a combination of histology, immunohistochemistry (IHC), and electron microscopy (EM) is enough to distinguish epithelioid mesothelioma from other cancers. However, some rare and unusual scenarios create gray areas, where even the best diagnostic tools struggle.